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The future of oral health

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The aMMP-8 and vitamin D check for your practice
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M.A.R.S. Research project 2025

M.A.R.S. simulation study Research project 2025

-Simulation study

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About the research project

About M.A.R.S.

Back in 2024, dentognostics joined the M.A.R.S. (Mars Analog Research Simulation) team's research project at UCLouvain for its upcoming mission. Due to the high relevance of the topic, we were also invited to accompany the M.A.R.S. simulation study in April 2025 with our in vitro diagnostics.

After all, healthy teeth for all crew members are essential for the success of the Mars missions, which can last up to two years. Astronauts are exposed to 700 times more cosmic radiation on their expeditions into space than on Earth. In combination with weightlessness, the stress associated with the mission and their diet, astronauts have a significantly higher risk of increased collagen degradation, which can lead to bone and tooth loss during the long Mars missions.

The biomarker aMMP-8 was used to test the international Atlas 2024 crew last year during their two-week expedition at the space training camp in Utah (USA). The easy-to-use saliva test uses a measuring device to provide information about the collagen status within a few minutes, which is elevated in the case of gum disease and stress, as stress has an impact on the human immune system.

The study in April 2025 is entitled “Longevity Effects of Substitution of a Collagen-Vitamin Micronutrition Form (CollagenSafe®) for the reduction of progressive Collagen Breakdown Activity (aMMP-8) of Astronauts in a simulated M.A.R.S. Mission environment”. The main topic here is: How can collagen breakdown be inhibited in astronauts in space? To this end, it is again controlled with aMMP-8 and inhibited by substituting a specific micronutrient formulation (CollagenSafe®), which promotes the regeneration of the astronauts.

Space research is so valuable for longevity research because astronauts accelerate their collagen degradation and therefore their ageing due to the influences they are exposed to in space. If we succeed in positively influencing this in space, we can benefit all the more from the findings on Earth.

Houston! Get your practice off to a flying start in 3,2,1... 

CollagenSafe® – soon available!
Are you a dental practice and would you also like astronaut technology for collagen regeneration for your patients?
Then get in touch with us here.

aMMP-8 is the ideal gauge for measuring collagen stability under the special conditions of a space mission. On Earth, this is a breakthrough for longevity research - we can finally measure the effectiveness of collagen & micronutrient therapy individually and tailor it to the needs of our patients.”

Dr. Dirk Neefs

DDS, NASA/ESA Dental Advisor, Space Health Dental Expert, Belgium

Atlas-Crew

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